2021 Hospital Dr, Clarksdale MS, 38614 · Phone: 662-624-6591 · Fax: 662-627-3389 · Mon-Fri: 9a.m.-6p.m. Sat & Sun: Closed

To our valued customers:

Due to the severity of the COVID-19 pandemic, we've taken extra steps to prioritize our patients' and employees' safety. At this time we will be serving all patients through our drive-thru window, curbside pickup, and delivery only.

Please call ahead and have your prescription number ready, or use our mobile app to refill.

The service you deserve from the neighbors you trust


Not just a pharmacy, but a family

On September 22nd 2014, your locally owned Henderson Drug and Economy Drug stores consolidated to form the newly named Henderson's Economy Drug. We are located at the old Economy Drug location at 2021 Hospital Drive.

We have been serving the Clarksdale area since 1926 and look forward to serving you, our friends and neighbors for many years to come. We offer charge accounts, delivery, home medical equipment and orthotic fittings. Our recent consolidation allows us to continue to serve you in the best way possible, while continuing to offer our fantastic low prices.

Pharmacy Services



We offer a variety of vaccines to keep you healthy. Contact us to learn more about our immunizations.

Durable Medical Equipment

Durable Medical Equipment

We carry a wide selection of medical equipment, including ambulatory aids, nebulizers and bathroom equipment.


Free Delivery

We offer free delivery to the nearby Clarksdale area. Contact us for details or to schedule your free delivery.

Download Our Free Mobile App

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Refill on-the-go

Refill your medications 24/7 on-the-go or when you're at home.

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User Profiles

Safely store your information and manage your list of prescriptions.

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Pill and Refill Reminders

Set reminders to take your meds or when it's time to refill.

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